Research has consistently demonstrated a negative relationship between acute alcohol withdrawal and alcohol self-administration in inbred strains of mice. However, the impact of age and sex of subject on acute alcohol withdrawal has received little to any research. This lack of research is detrimental to understanding factors that may influence alcohol self administration across the lifespan, an important healthcare question considering the increased alcohol consumption in the aged population. The current experiment investigates acute alcohol withdrawal in three commonly used inbred strains of mice at several time points across their lifespan. In addition, acute alcohol withdrawal is determined in both female and male subjects to ascertain the impact of sex on withdrawal across the lifespan. We present data showing age and sex difference in response to an alcohol challenge. These data further highlight the importance of investigating both sex and age in relation to alcohol's effects and provides foundational work to investigate alcohol self-administration across the lifespan.
