The study explores the perspective of important stakeholders in nursing home care to better understand the difficulties and opportunities for improvement regarding care and quality of life for residents living with dementia and comorbidities. The research can guide interventions to address these challenges and enhance care. The study involved semi-structured interviews with 13 stakeholders from a family-run nursing home in 2024. Participants included care assistants, well-being companions, a registered nurse, the manager, the owner, a general practitioner (GP), and informal caregivers. Interviews were conducted online via Microsoft Teams, and thematic analysis was used to identify key challenges and factors involved. Five key challenges emerged, including managing the consequences of dementia, addressing staff knowledge gaps, creating inclusive services, compensating for an under-resourced healthcare system, and understanding caregiver responsibilities. Eight facilitating factors were also identified, such as a holistic approach to care and ensuring continuity and personalization. The findings suggested that psycho-educational interventions to improve clinical care and geriatric knowledge, in addition to basic psychological training for staff, can help to address these challenges. These suggestions try to improve interactions with families, enhance the quality of care, and ultimately improve the quality of life for nursing home residents with dementia and comorbidities.