This study investigates the challenges and potential solutions in caring for nursing home residents in the U.S. who have dementia and other comorbidities. Data was gathered from 35 staff members—Directors of Nursing, Certified Nursing Assistants, physicians, administrators, and social workers—across eight nursing facilities in Iowa, Minnesota, and Wisconsin. Participants completed a four-question open-ended survey that explored the challenges in managing dementia and comorbidities, their causes, and potential solutions. Key issues identified include difficulties in managing mental health conditions and chronic diseases, staffing shortages, communication barriers, and unrealistic family expectations. The study recommends strategies to improve care quality, such as increasing state funding for dementia programs, ensuring adequate staffing, providing comprehensive dementia training, maintaining consistent caregivers, and offering support resources for families. These interventions aim to enhance the quality of life for residents with dementia and comorbidities.